{"data":{"id":213354,"slug":"bitradande-forskare-leukemicellers-vilotillstand-och-behandlingsresistens","type":"job","title":"Postdoctoral Researcher, Leukemic Cell Quiescence and Treatment Resistance","description":"Lund University was founded in 1666 and is consistently ranked among the world's leading universities. Here there are approximately 46,000 students and 8,500 employees in Lund, Helsingborg, and Malm\u00f6. We are united in our commitment to understand, explain, and improve our world and people's conditions.\nDescription of the Workplace\nThe research group is part of the Division of Molecular Medicine and Gene Therapy at the Faculty of Medicine, Lund University.\nIn B-cell acute lymphoblastic leukemia (B-ALL) in children, a subpopulation of leukemic cells survives chemotherapy by entering a quiescent state. These cells are believed to contribute to minimal residual disease and subsequently cause relapse. The research group investigates the mechanisms underlying this process using a bone marrow organoid model based on human induced pluripotent stem cells (iPSCs), which are transplanted with primary ALL cells. The model enables studies of the interaction between leukemic cells and the bone marrow microenvironment that governs the transition to quiescence.\nThis research platform is combined with an expressed barcode system that enables simultaneous tracking of cell lineage, cell state, and cell cycle dynamics at the single-cell level.\nThe project is conducted in collaboration with UCL Cancer Institute, where Professor Tariq Enver holds his primary position. The research group is jointly led by Professor Enver, who is also a visiting professor at Lund University, and Dr. Virginia Turati. The group also consists of doctoral students and postdoctoral researchers.\nWe are committed to maintaining a positive, inclusive, and respectful work environment where all colleagues are treated with consideration, respect, and professionalism.\nWhat We Offer\nLund University is a state agency, which means you receive special benefits, generous vacation time, and a favorable occupational pension. We also have a flexible working time agreement that creates good conditions for work-life balance. Learn more on the university's website about working at Lund University, Work with Us.\nResponsibilities and Areas of Responsibility\nImplementation, optimization, and maintenance of the research group's human bone marrow organoid model, including engraftment of primary ALL cells and experiments with chemotherapy exposure.\nIsolation and characterization of quiescent, chemotherapy-resistant (label-retaining) ALL cells using flow cytometry, cell sorting, and functional analyses.\nApplication and further development of the research group's expressed lineage barcoding platform, including lentiviral transduction of ALL cells for simultaneous tracking of cell lineage, cell state, and cell cycle dynamics.\nConducting molecular characterization and profiling of quiescent and treatment-resistant leukemic cell states.\nResponsibility for careful documentation of experiments and contribution to the research group's work on quality assurance, reproducibility, and data management.\nParticipation in writing scientific manuscripts, scientific communication, and presentation of research results at national and international conferences.\nCo-mentoring of master's students and doctoral students within the research group.\n\nQualifications\nRequirements for Employment\nPh.D. in cell biology, molecular biology, stem cell biology, hematology, cancer biology, or a related research field.\nDocumented practical experience with culturing human stem cells\/progenitor cells, such as iPSC-based systems, primary hematopoietic cells, or primary leukemia samples.\nExperience with flow cytometry and cellular functional analyses.\nAbility to independently plan, conduct, and analyze research projects.\nVery strong ability to express yourself orally and in writing in English.\n\nMeritorious\nExperience with 3D culture, organoid models, or tissue engineering systems.\nExperience with genetic modification of mammalian cells using lentivirus or other virus vector-based methods.\nExperience with genome editing using CRISPR\/Cas9.\nExperience with research in leukemia biology, hematopoiesis, stem cell biology, or treatment resistance in cancer.\nExperience with mentoring, advising, or training of students and junior researchers.\nPrevious experience with research in similar projects.\n\nOther Information\nThe position is temporary according to S\u00c4VA for 12 months and is full-time. Start date is November 15 or by agreement.\nHow to Apply\nThe position is filled through the university's recruitment system. Your application should include a cover letter describing how you meet the qualification requirements and why you are interested in the position. Your application should also include a CV, including a publication list, a general description of previous research work, a copy of your doctoral degree, and anything else you wish to submit (copies of diplomas, transcripts, references, letters of recommendation, etc.)\nThe university applies individual salary determination. Please include salary expectations in your application.\nThe Faculty of Medicine is an operational area within Lund University, responsible for education and research in medicine, care, and health. Education is conducted in close collaboration with healthcare and is well anchored in the faculty's strong research tradition. The faculty's research spans a broad field of experimental basic research, patient-oriented clinical research, and health science research. The Faculty of Medicine, with over 1,800 employees and 3,000 students in Lund, Malm\u00f6, and Helsingborg, is a knowledge-intensive meeting place for students, teachers, and researchers from around the world.\nThe Department of Laboratory Medicine (ILM) is one of six departments at the Faculty of Medicine. We conduct leading research in the laboratory medicine field with a focus on how diseases develop and how we can improve patient diagnosis and treatment. Some of our strongest areas of world-class research involve cancer, genetics, and blood research.\nWe decline all contact from advertising sales, recruitment and staffing companies due to government procurement regulations.","language":"sv","is_translated":true,"title_original":"Bitr\u00e4dande forskare, leukemicellers vilotillst\u00e5nd och behandlingsresistens.","description_original":"Lunds universitet grundades 1666 och rankas \u00e5terkommande som ett av v\u00e4rldens fr\u00e4msta l\u00e4ros\u00e4ten. H\u00e4r finns omkring 46 000 studenter och 8 500 medarbetare i Lund, Helsingborg och Malm\u00f6. Vi f\u00f6renas i v\u00e5r str\u00e4van att f\u00f6rst\u00e5, f\u00f6rklara och f\u00f6rb\u00e4ttra v\u00e5r v\u00e4rld och m\u00e4nniskors villkor.\nBeskrivning av arbetsplatsen\nForskargruppen \u00e4r en del av Avdelningen f\u00f6r molekyl\u00e4r medicin och genterapi vid Medicinska fakulteten, Lunds universitet.\nVid B-cells akut lymfatisk leukemi (B-ALL) hos barn \u00f6verlever en undergrupp av leukemiceller kemoterapi genom att g\u00e5 in i ett vilande, quiescent tillst\u00e5nd. Dessa celler tros bidra till minimal kvarvarande sjukdom (minimal residual disease) och i f\u00f6rl\u00e4ngningen orsaka \u00e5terfall. Forskargruppen unders\u00f6ker de mekanismer som ligger bakom denna process med hj\u00e4lp av en benm\u00e4rgsorganoidmodell baserad p\u00e5 humana inducerade pluripotenta stamceller (iPSC), som transplanteras med prim\u00e4ra ALL-celler. Modellen m\u00f6jligg\u00f6r studier av samspelet mellan leukemiceller och benm\u00e4rgsmilj\u00f6n som styr \u00f6verg\u00e5ngen till quiescens.\nDenna forskningsplattform kombineras med ett system f\u00f6r uttryckt streckkodning (expressed barcoding) som m\u00f6jligg\u00f6r samtidig sp\u00e5rning av cellinje, celltillst\u00e5nd och cellcykeldynamik p\u00e5 encellsniv\u00e5.\nProjektet genomf\u00f6rs i samarbete med UCL Cancer Institute, d\u00e4r professor Tariq Enver har sin huvudsakliga anst\u00e4llning. Forskargruppen leds gemensamt av professor Enver, som \u00e4ven \u00e4r g\u00e4stprofessor vid Lunds universitet, och doktor Virginia Turati. Gruppen best\u00e5r dessutom av doktorander och postdoktorala forskare.\nVi \u00e4r engagerade i att uppr\u00e4tth\u00e5lla en positiv, inkluderande och respektfull arbetsmilj\u00f6 d\u00e4r alla kollegor bem\u00f6ts med h\u00e4nsyn, respekt och professionalism\nVi erbjuder\nLunds universitet \u00e4r en statlig myndighet vilket inneb\u00e4r att du f\u00e5r s\u00e4rskilda f\u00f6rm\u00e5ner, gener\u00f6s semester och en f\u00f6rm\u00e5nlig tj\u00e4nstepension. Vi har \u00e4ven ett flextidsavtal som skapar goda f\u00f6ruts\u00e4ttningar f\u00f6r balans mellan arbete och fritid. \u00a0L\u00e4s mer p\u00e5 universitetets webbplats om att vara anst\u00e4lld vid Lunds universitet, Jobba hos oss\u00a0\nArbetsuppgifterna och ansvarsomr\u00e5den\nImplementering, optimering och underh\u00e5ll av forskargruppens humana benm\u00e4rgsorganoidmodell, inklusive engraftment (etablering) av prim\u00e4ra ALL-celler och experiment med exponering f\u00f6r kemoterapi.\n\u00a0Isolering och karakterisering av vilande, kemoterapiresistenta (label-retaining) ALL-celler med hj\u00e4lp av fl\u00f6descytometri, cellsortering och funktionella analyser.\nTill\u00e4mpning och vidareutveckling av forskargruppens plattform f\u00f6r linjesp\u00e5rning med uttryckt streckkodning (expressed lineage barcoding), inklusive lentiviral transduktion av ALL-celler f\u00f6r samtidig sp\u00e5rning av cellinje, celltillst\u00e5nd och cellcykeldynamik.\nGenomf\u00f6rande av molekyl\u00e4r karakterisering och profilering av vilande och behandlingsresistenta leukemiska celltillst\u00e5nd.\nAnsvar f\u00f6r noggrann dokumentation av experiment samt bidrag till forskargruppens arbete med kvalitetss\u00e4kring, reproducerbarhet och datahantering.\nMedverkan i f\u00f6rfattande av vetenskapliga manuskript, vetenskaplig kommunikation samt presentation av forskningsresultat vid nationella och internationella konferenser.\nMedhandledning av masterstudenter och doktorander inom forskargruppen.\n\nKvalifikationer\nKrav f\u00f6r anst\u00e4llningen\nDoktorsexamen i cellbiologi, molekyl\u00e4rbiologi, stamcellsbiologi, hematologi, cancerbiologi eller ett n\u00e4rliggande forskningsomr\u00e5de.\nDokumenterad praktisk erfarenhet av odling av humana stamceller\/progenitorceller, exempelvis iPSC-baserade system, prim\u00e4ra hematopoetiska celler eller prim\u00e4ra leukemiprover.\nErfarenhet av fl\u00f6descytometri och cellul\u00e4ra funktionsanalyser.\nF\u00f6rm\u00e5ga att sj\u00e4lvst\u00e4ndigt planera, genomf\u00f6ra och analysera forskningsprojekt.\nMycket god f\u00f6rm\u00e5ga att uttrycka sig i tal och skrift p\u00e5 engelska.\n\nMeriterande\nErfarenhet av 3D-odling, organoidmodeller eller v\u00e4vnadstekniska system.\nErfarenhet av genetisk modifiering av d\u00e4ggdjursceller med lentivirus eller andra virusvektorbaserade metoder.\nErfarenhet av genomredigering med CRISPR\/Cas9.\nErfarenhet av forskning inom leukemibiologi, hematopoes, stamcellsbiologi eller behandlingsresistens vid cancer.\nErfarenhet av handledning, mentorskap eller utbildning av studenter och juniora forskare.\nTidigare erfarenhet av forskning inom liknande projekt.\n\n\u00d6vrigt\nAnst\u00e4llningen \u00e4r tidsbegr\u00e4nsad enligt S\u00c4VA 12 m\u00e5nader och omfattar heltid. Tilltr\u00e4de sker den 15 november eller enligt \u00f6verenskommelse.\nS\u00e5 h\u00e4r s\u00f6ker du\nAnst\u00e4llningen s\u00f6ks via universitetets rekryteringssystem. Ans\u00f6kan ska inneh\u00e5lla ett personligt brev d\u00e4r du beskriver hur du uppfyller kvalifikationskraven samt varf\u00f6r du \u00e4r intresserad av anst\u00e4llningen. Ans\u00f6kan ska \u00e4ven inneh\u00e5lla CV, inklusive publikationslista, en generell beskrivning av tidigare forskningsarbete, kopia av doktorsexamen samt \u00f6vrigt som du \u00f6nskar \u00e5beropa (kopior av examensbevis, betyg, uppgifter till referenser, rekommendationsbrev etc.)\nUniversitetet till\u00e4mpar individuell l\u00f6nes\u00e4ttning. Ange g\u00e4rna l\u00f6neanspr\u00e5k i din ans\u00f6kan.\nMedicinska fakulteten \u00e4r ett verksamhetsomr\u00e5de inom Lunds universitet, med ansvar f\u00f6r utbildning och forskning inom medicin, v\u00e5rd och h\u00e4lsa. Utbildningen sker i n\u00e4ra samverkan med sjukv\u00e5rden och \u00e4r v\u00e4l f\u00f6rankrad i fakultetens starka forskningstradition. Fakultetens forskning sp\u00e4nner \u00f6ver ett brett f\u00e4lt inom experimentell grundforskning, patientn\u00e4ra klinisk forskning och h\u00e4lsovetenskaplig forskning. Medicinska fakulteten, med drygt 1800 anst\u00e4llda och 3000 studenter i Lund, Malm\u00f6 och Helsingborg, \u00e4r en kunskapsintensiv m\u00f6tesplats f\u00f6r studenter, l\u00e4rare och forskare fr\u00e5n hela v\u00e4rlden.\nInstitutionen f\u00f6r laboratoriemedicin (ILM) \u00e4r en av sex institutioner vid Medicinska fakulteten. Vi bedriver ledande forskning inom det laboratoriemedicinska f\u00e4ltet med fokus p\u00e5 hur sjukdomar uppkommer och hur vi kan f\u00f6rb\u00e4ttra patienters diagnostik och behandling. N\u00e5gra av v\u00e5ra starkaste omr\u00e5den med forskning i v\u00e4rldsklass, handlar om cancer-, genetik- och blodforskning.\nVi undanber oss alla kontakter fr\u00e5n annonsf\u00f6rs\u00e4ljare, rekryterings- och bemanningsf\u00f6retag p\u00e5 grund av statliga upphandlingsregler.","price":null,"currency":"SEK","status":"active","noindex":true,"location":{"address":"S\u00f6lvegatan 19","full_address":null,"city":"Lund","country":"SE","latitude":55.711101388146,"longitude":13.202579146529},"metadata":{"region":"Sk\u00e5ne l\u00e4n","duration":"6 m\u00e5nader eller l\u00e4ngre","employer":"Lunds Universitet","postcode":"22362","positions":1,"profession":"Forskarassistent","salary_type":"Fast m\u00e5nads- vecko- eller timl\u00f6n","employer_url":"https:\/\/www.lu.se\/vacancies","scope_of_work":"100\u2013100 %","working_hours":"Heltid","contact_person":"SACO:Saco-s-r\u00e5det vid Lunds universitet","employment_type":"full_time","occupation_field":"Pedagogik","employer_workplace":"Lunds universitet, Medicinska fakulteten, inst f\u00f6r laboratoriemedicin","experience_required":true,"employment_type_label":"Vanlig anst\u00e4llning"},"user_id":null,"is_sponsored":false,"views_count":0,"ai_views_count":3,"bot_views_count":2,"ai_vendor_counts":{"openai":2,"anthropic":1},"visibility":"public","submission_source":null,"submission_ai_name":null,"has_owner_email":true,"can_contact_owner":true,"phone":"046-2220000","owner_email":"kansli@saco-s.lu.se","images":[],"published_at":"2026-09-15T14:16:39+00:00","expires_at":"2026-09-30T23:59:59+00:00","created_at":"2026-09-16T03:22:12+00:00","updated_at":"2026-09-19T03:09:05+00:00"}}