{"data":{"id":197600,"slug":"forskare-20","type":"job","title":"Researcher","description":"University of Gothenburg meets society's challenges with diverse expertise. 58,000 students and 6,800 employees make the university a large and inspiring workplace. Strong research and attractive programs attract researchers and students from around the world. With new knowledge and new perspectives, University of Gothenburg contributes to a better future.\n \nThe Department of Medicine, Division of Molecular and Clinical Medicine, conducts translational research primarily on metabolism, diabetes, obesity, and cardiovascular disease with the aim of improving health and healthcare in society. The overarching goal is to create an excellent translational research environment of very high international standard.\n \nThe gut microbiota constitutes a complex ecosystem with enormous genetic and functional diversity that can affect our physiology, metabolism, and health. Despite this, the microbiota remains largely unexplored as a source of biological functions that could be utilized to prevent and treat disease. By identifying enzymes from gut bacteria and optimizing their function, we aim to develop new ways to influence metabolism directly in the gut. We are now seeking a researcher who wants to explore the enzymatic potential of the gut microbiota and develop microbial enzyme functions that can improve our health and prevent disease.\n \nResponsibilities\nIdentify and characterize bacterial enzymes that metabolize phenylalanine and investigate how their structure affects enzyme activity and substrate specificity. The successful candidate will clone and express genes for selected enzymes and determine their enzyme kinetics and biochemical properties. Subsequently, the candidate will use structure-based and computational protein design to generate and test enzyme variants with improved activity, stability, and specificity for phenylalanine. Finally, optimized enzymes will be evaluated in microbial and experimental models to investigate their potential to affect phenylalanine metabolism.\n \nQualifications\nThe position requires a doctorate in biochemistry, microbiology, or a related field. You must have documented research experience in microbial enzymology, including identification and functional characterization of microbial enzymes. You must have experience with recombinant protein expression, protein purification, and quantitative biochemical characterization of enzymes, including enzyme activity measurements and analysis of substrate specificity. Documented experience in experimental structural protein biology, particularly X-ray crystallography and structure-based analysis of enzyme function, is also required. You must have a strong scientific publication record in microbial metabolism, enzymology, structural biology, synthetic biology, microbiome research, or related areas. You must be able to express yourself well in English in both speech and writing.\n \nExperience studying microbial metabolism of small molecules, such as aromatic compounds, polyphenols, or amino acid-derived metabolites, with HPLC and\/or mass spectrometry is highly meritorious. Experience with microbial genetic manipulation and functional genetics, including genetic manipulation of non-model organisms, is also highly meritorious. Experience with anaerobic cultivation of bacteria, particularly gut-associated bacteria or Clostridia, in so-called Coy chambers is highly meritorious.\n \nExperience integrating metagenomic and metatranscriptomic data with experimental characterization of microbial functions is meritorious. Experience with protein engineering, including structure-based mutagenesis, rational enzyme design, directed evolution, or functional screening, is also meritorious. Knowledge of computational protein design, machine learning-based protein engineering, or AI-based protein design is additionally meritorious.\n \nIt is important that the candidate is creative, able to work independently, and at the same time collaborate well with other researchers and clinicians within a larger team. We place great emphasis on personal suitability.\n \nEmployment\nEmployment type: Permanent\nExtent: 100%\nLocation: Department of Medicine, Gothenburg.\nStart date: 2027-01-01 or by agreement.\n \nContact Information for the Position\nFredrik B\u00e4ckhed\nProfessor\n+46 (0)702-182 355\nfredrik.backhed@wlab.gu.se\n \nMalin Levin\nDepartment Head\nmalin.levin@wlab.gu.se\n \nTrade Union Representatives\nTrade union representatives at University of Gothenburg can be found here: https:\/\/www.gu.se\/jobba-hos-oss\/sa-blir-du-en-av-oss#kollektivavtal-och-fackliga-foretradare\n \nApplication\nAttach doctoral degree certificate, personal letter, CV, and names of 2-3 references with your application.\n \nYou apply for the position through University of Gothenburg's recruitment portal by registering your application electronically via the website: https:\/\/www.gu.se\/om-universitetet\/jobba-hos-oss\/lediga-anstallningar. As an applicant, you are responsible for ensuring that your application is complete in accordance with the advertisement and that it is received by the university no later than the final application deadline.\n \nApplication deadline: 2026-09-28\n \nThe university actively works for a work environment with equal conditions and values the qualities that diversity brings to the organization. The university applies individual salary setting. According to the regulations of the National Archives, the university is obligated to retain application documents for two years after the hiring decision. If you as an applicant specifically request the return of your documents, they will be returned when the two years have elapsed; otherwise, they will be disposed of. To staffing and recruitment companies and to you who are job advertisement sellers: University of Gothenburg uses contracted advertising agencies in connection with recruitment of staff. We kindly but firmly decline direct contact from staffing and recruitment companies and sellers of job advertisements.","language":"sv","is_translated":true,"title_original":"Forskare","description_original":"G\u00f6teborgs universitet m\u00f6ter samh\u00e4llets utmaningar med m\u00e5ngsidig kunskap. 58 000 studenter och 6800 medarbetare g\u00f6r universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter fr\u00e5n hela v\u00e4rlden. Med ny kunskap och nya perspektiv bidrar G\u00f6teborgs universitet till en b\u00e4ttre framtid.\n\u00a0\nInstitutionen f\u00f6r medicin, Avdelningen f\u00f6r molekyl\u00e4r och klinisk medicin, bedriver translationell forskning fr\u00e4mst kring metabolism, diabetes, fetma och kardiovaskul\u00e4r sjukdom i syfte att f\u00f6rb\u00e4ttra h\u00e4lsa och sjukv\u00e5rd i samh\u00e4llet. Det \u00f6vergripande m\u00e5let \u00e4r att skapa en excellent translationell forskningsmilj\u00f6 av mycket h\u00f6g internationell standard.\n\u00a0\nTarmmikrobiotan utg\u00f6r ett komplext ekosystem med en enorm genetisk och funktionell m\u00e5ngfald som kan p\u00e5verka v\u00e5r fysiologi, metabolism och h\u00e4lsa. Trots detta \u00e4r mikrobiotan fortfarande en till stor del outforskad k\u00e4lla till biologiska funktioner som skulle kunna utnyttjas f\u00f6r att f\u00f6rebygga och behandla sjukdom. Genom att identifiera enzymer fr\u00e5n tarmens bakterier och optimera deras funktion vill vi utveckla nya s\u00e4tt att p\u00e5verka \u00e4mnesoms\u00e4ttningen direkt i tarmen. Vi s\u00f6ker nu en forskare som vill vara med och utforska tarmmikrobiotans enzymatiska potential och utveckla mikrobiella enzymfunktioner som kan f\u00f6rb\u00e4ttra v\u00e5r h\u00e4lsa och motverka sjukdom.\n\u00a0\nArbetsuppgifter\u00a0\nIdentifiera och karakt\u00e4risera bakteriella enzymer som metaboliserar fenylalanin och unders\u00f6ka hur deras struktur p\u00e5verkar enzymaktivitet och substratspecificitet. Den s\u00f6kande kommer att klona och uttrycka gener f\u00f6r utvalda enzymer samt best\u00e4mma deras enzymkinetik och biokemiska egenskaper. D\u00e4refter kommer den s\u00f6kande att anv\u00e4nda strukturbaserad och ber\u00e4kningsbaserad proteindesign f\u00f6r att generera och testa enzymvarianter med f\u00f6rb\u00e4ttrad aktivitet, stabilitet och specificitet f\u00f6r fenylalanin. Slutligen kommer optimerade enzymer att utv\u00e4rderas i mikrobiella och experimentella modeller f\u00f6r att unders\u00f6ka deras potential att p\u00e5verka fenylalaninmetabolismen.\n\u00a0\nKvalifikationer\u00a0\nF\u00f6r anst\u00e4llningen kr\u00e4vs att du \u00e4r disputerad inom biokemi, mikrobiologi eller n\u00e4rliggande \u00e4mne. Det \u00e4r ett krav att du har dokumenterad forskningserfarenhet inom mikrobiell enzymologi, inklusive identifiering och funktionell karakt\u00e4risering av mikrobiella enzymer. Du ska ha erfarenhet av rekombinant proteinuttryck, proteinrening och kvantitativ biokemisk karakt\u00e4risering av enzymer, inklusive enzymaktivitetsm\u00e4tningar och analys av substratspecificitet. Dokumenterad erfarenhet av experimentell strukturell proteinbiologi, s\u00e4rskilt r\u00f6ntgenkristallografi och strukturbaserad analys av enzymers funktion, \u00e4r ocks\u00e5 ett krav. Du ska \u00e4ven ha en stark vetenskaplig publikationslista inom mikrobiell metabolism, enzymologi, strukturbiologi, syntetisk biologi, mikrobiomforskning eller n\u00e4rliggande omr\u00e5den. Du ska kunna uttrycka dig v\u00e4l p\u00e5 engelska i b\u00e5de tal och skrift.\u00a0\n\u00a0\nErfarenhet av att studera mikrobiell metabolism av sm\u00e5 molekyler, s\u00e5som aromatiska f\u00f6reningar, polyfenoler eller aminosyraderiverade metaboliter, med HPLC och\/eller masspektrometri \u00e4r starkt meriterande. Erfarenhet av mikrobiell genetisk manipulering och funktionell genetik, inklusive genetisk manipulering av icke-modellorganismer, \u00e4r ocks\u00e5 starkt meriterande. Erfarenhet av anaerob odling av bakterier, s\u00e4rskilt tarmassocierade bakterier eller Clostridia, i s\u00e5 kallad Coy-kammare \u00e4r starkt meriterande.\n\u00a0\nErfarenhet av att integrera metagenomiska och metatranskriptomiska data med experimentell karakt\u00e4risering av mikrobiella funktioner \u00e4r meriterande. Erfarenhet av protein engineering, inklusive strukturbaserad mutagenes, rationell enzymdesign, riktad evolution eller funktionell screening, \u00e4r ocks\u00e5 meriterande. Kunskaper inom ber\u00e4kningsbaserad proteindesign, maskininl\u00e4rningsbaserad protein engineering eller AI-baserad proteindesign \u00e4r ytterligare meriterande.\n\u00a0\nDet \u00e4r viktigt att den s\u00f6kande \u00e4r kreativ, kan arbeta sj\u00e4lvst\u00e4ndigt, men samtidigt samarbeta v\u00e4l med andra forskare och kliniker inom ett st\u00f6rre team och vi l\u00e4gger stor vikt vid personlig l\u00e4mplighet.\n\u00a0\nAnst\u00e4llning\u00a0\nAnst\u00e4llningsform: Tillsvidare\nOmfattning: 100%\nPlacering: Institutionen f\u00f6r medicin, G\u00f6teborg.\nTilltr\u00e4de: 2027-01-01 eller enligt \u00f6verenskommelse.\n\u00a0\nKontaktuppgifter f\u00f6r anst\u00e4llningen\u00a0\nFredrik B\u00e4ckhed\nProfessor\n+46 (0)702-182 355\nfredrik.backhed@wlab.gu.se\n\u00a0\nMalin Levin\u00a0\nAvdelningschef\nmalin.levin@wlab.gu.se\n\u00a0\nFackliga\u202forganisationer\u00a0\nFackliga f\u00f6retr\u00e4dare vid G\u00f6teborgs universitet hittar du h\u00e4r:\u202fhttps:\/\/www.gu.se\/jobba-hos-oss\/sa-blir-du-en-av-oss#kollektivavtal-och-fackliga-foretradare\n\u00a0\nAns\u00f6kan\u00a0\nBifoga doktorsexamensbevis, personligt brev, CV och namn p\u00e5 2-3 referenser vid ans\u00f6kan.\n\u00a0\nDu s\u00f6ker anst\u00e4llningen via G\u00f6teborgs universitets rekryteringsportal genom att registrera din ans\u00f6kan elektroniskt via hemsidan: https:\/\/www.gu.se\/om-universitetet\/jobba-hos-oss\/lediga-anstallningar. Du som s\u00f6kande ansvarar f\u00f6r att ans\u00f6kan \u00e4r komplett i enlighet med annonsen och att den \u00e4r universitetet tillhanda senast sista ans\u00f6kningsdag.\n\u00a0\nAns\u00f6kan ska vara inkommen senast: 2026-09-28\n\u00a0\nUniversitetet arbetar aktivt f\u00f6r en arbetsmilj\u00f6 med j\u00e4mst\u00e4llda f\u00f6rh\u00e5llanden och s\u00e4tter v\u00e4rde p\u00e5 de kvalit\u00e9er m\u00e5ngfald tillf\u00f6r verksamheten. Universitetet till\u00e4mpar individuell l\u00f6nes\u00e4ttning. Enligt Riksarkivets f\u00f6reskrifter \u00e4r universitetet skyldigt att f\u00f6rvara ans\u00f6kningshandlingar i tv\u00e5 \u00e5r efter tills\u00e4ttningsbeslutet. Om du som s\u00f6kande till en anst\u00e4llning s\u00e4rskilt beg\u00e4r tillbaka dina handlingar \u00e5ters\u00e4nds de n\u00e4r de tv\u00e5 \u00e5ren har f\u00f6rflutit, i annat fall kommer de att gallras ut. Till bemannings- och rekryteringsf\u00f6retag och till dig som \u00e4r f\u00f6rs\u00e4ljare: G\u00f6teborgs universitet anlitar upphandlad annonsbyr\u00e5 i samband med rekrytering av personal. Vi undanber oss v\u00e4nligen men best\u00e4mt direktkontakt med bemannings- och rekryteringsf\u00f6retag samt f\u00f6rs\u00e4ljare av jobbannonser.","price":null,"currency":"SEK","status":"active","noindex":true,"location":{"address":null,"full_address":null,"city":"G\u00f6teborg","country":"SE","latitude":57.7119231,"longitude":11.9822532},"metadata":{"region":"V\u00e4stra G\u00f6talands l\u00e4n","duration":"Tills vidare","employer":"G\u00f6teborgs Universitet","postcode":"41345","positions":1,"profession":"Forskare, medicin","salary_type":"Fast m\u00e5nads- vecko- eller timl\u00f6n","employer_url":"https:\/\/www.gu.se\/","scope_of_work":"100\u2013100 %","working_hours":"Heltid","employment_type":"full_time","occupation_field":"Naturvetenskap","employer_workplace":"G\u00f6teborgs Universitet (GU)","experience_required":true,"employment_type_label":"Vanlig anst\u00e4llning"},"user_id":null,"is_sponsored":false,"views_count":0,"ai_views_count":11,"bot_views_count":0,"ai_vendor_counts":{"meta":3,"other":2,"openai":3,"anthropic":3},"visibility":"public","submission_source":null,"submission_ai_name":null,"has_owner_email":true,"can_contact_owner":true,"phone":"702-182 355","owner_email":"fredrik.backhed@wlab.gu.se","images":[],"published_at":"2026-09-07T08:51:34+00:00","expires_at":"2026-09-28T23:59:59+00:00","created_at":"2026-09-08T03:46:49+00:00","updated_at":"2026-09-18T03:19:28+00:00"}}