{"data":{"id":148910,"slug":"postdoktor-for-studier-av-komplement-i-den-aldrande-karlvaggen","type":"job","title":"Postdoctoral Fellow for Studies of Complement in the Aging Blood Vessel","description":"Lund University was founded in 1666 and is consistently ranked among the world's leading academic institutions. It has approximately 46,000 students and 8,500 employees in Lund, Helsingborg, and Malm\u00f6. We are united in our mission to understand, explain, and improve our world and people's conditions.\n\nWorkplace Description\nThe postdoctoral position is located in the Cellular Biomechanics research group within the Vascular Physiology research environment at the Department of Experimental Medical Science (EMV), Faculty of Medicine, Lund University. EMV conducts molecular, cellular, and integrative research at the highest international level and trains tomorrow's leading researchers.\n\nThe Vascular Physiology research environment comprises three research groups and approximately ten active researchers. The activities are located at BMC D12 and have access to 300 m\u00b2 of laboratory and office spaces with modern infrastructure for physiology and cell biology. The environment includes two professors, two senior lecturers, as well as doctoral students, postdoctoral fellows, and technical staff. The expertise encompasses transgenic models, in vivo physiology, and advanced bioinformatics, with close connections to university platforms for imaging and omics.\n\nThe recruited researcher will study the significance of the complement system in age-related vascular disease. The work involves development and characterization of transgenic models that mimic age-related changes in complement activity. The postdoctoral fellow will also participate in ongoing collaborative projects, including an active collaboration with researchers at the University of Copenhagen within an initiative funded by the Novo Nordisk Foundation.\n\nThe Department offers an inclusive research environment characterized by respect, openness, and collaboration. Professional development is encouraged through flexible working conditions that promote well-being. With a focus on equality, structured leadership, and well-developed occupational health practices, EMV provides a sustainable and stimulating environment for research and career development.\n\nProject Description\nOur research combines experimental approaches with analyses of human biobank material and clinical databases to understand how mechanical forces regulate gene expression. We have recently mapped transcriptomic changes in arteries from aging humans and rodents (https:\/\/doi.org\/10.1016\/j.jbc.2025.108400; https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.125.26119) and now aim to clarify the underlying mechanisms by developing transgenic models and investigating their significance for vascular function and vascular disease.\n\nA central goal is to model increased expression of the complement system in aging arteries, where the postdoctoral fellow is expected to contribute to collaborative projects with the University of Copenhagen and the University of Gothenburg. The work is funded by several major Swedish research funding agencies, with specific support for the postdoctoral position from the Novo Nordisk Foundation (https:\/\/novonordiskfonden.dk\/en\/grant-recipient\/?category=72&paginate=1&sort=DESC&search=metabolic+ageing). The position offers excellent opportunities to develop an independent and internationally competitive research profile in leading Nordic research environments.\n\nThe project is part of the Novo Nordisk Foundation's initiative Metabolic Ageing \u2013 Collaborative Project Grants, which provides opportunities to participate in joint workshops, symposia, research exchanges, and other networking and dissemination activities together with affiliated research groups studying metabolic aging.\n\nDuties and Responsibilities\nAt Lund University, a postdoctoral position should provide the opportunity for scientific and pedagogical qualification and advancement. Priority is given to opportunities for qualification within research, but also to some extent higher education pedagogical training. Teaching may also be included in the job duties.\n\nSeveral complement factors increase in the arterial wall with advancing age. Since complement factor H (Cfh) limits complement activation on tissue surfaces, vascular knockout of Cfh constitutes a synthetic aging model expected to promote pathological processes such as atherosclerosis and aneurysm formation.\n\nTo investigate this, you will generate cell-specific and inducible knockout mice by crossing endothelial (Tie1) and smooth muscle cell-specific (Itga8) Cre lines with mice carrying floxed Cfh alleles (https:\/\/mice.jax.org\/). Genotyping is performed externally, but you will be responsible for colony and tissue sample management, including breeding strategy, cage planning, and tamoxifen treatment for inducible knockout models. You will also plan and conduct experiments in close collaboration with colleagues, which on occasion may involve work outside regular working hours.\n\nVascular phenotypes will be analyzed using histological and physiological methods, including disease models based on hypercholesterolemia and hypertension. Systemic complement activation and potential kidney effects will also be investigated. In addition to leading the work with the Cfh models, you will collaborate closely with our research partners at the University of Copenhagen and contribute to ongoing studies of mechanically regulated transcription in the arterial wall.\n\nYou are expected to present your results at international conferences, within the research environment, and in the broader collaborative network. Funding from the Novo Nordisk Foundation includes an annual travel allowance for participation in symposia as well as funds for operating costs and laboratory costs (bench fee).\n\nQualifications\nRequirements for employment:\nDoctorat\u0435 degree or equivalent foreign degree in physiology, pharmacology, molecular biology, or experimental medical science. The doctorate must be completed, or alternatively the dissertation must be submitted and approved for defense, no later than when the employment decision is made.\nStrong ability to develop and conduct high-quality research.\nPedagogical ability.\nExcellent collaboration skills and ability to work independently.\nVery strong ability to communicate in English, both orally and in writing, with the ability to clearly present research results and communicate with both the research group and external collaborators and other stakeholders.\n\nPlease see the full announcement via this link: https:\/\/lu.varbi.com\/what:job\/jobID:955286\/","language":"sv","is_translated":true,"title_original":"Postdoktor f\u00f6r studier av komplement i den \u00e5ldrande k\u00e4rlv\u00e4ggen","description_original":"Lunds universitet grundades 1666 och rankas \u00e5terkommande som ett av v\u00e4rldens fr\u00e4msta l\u00e4ros\u00e4ten. H\u00e4r finns omkring 46 000 studenter och 8 500 medarbetare i Lund, Helsingborg och Malm\u00f6. Vi f\u00f6renas i v\u00e5r str\u00e4van att f\u00f6rst\u00e5, f\u00f6rklara och f\u00f6rb\u00e4ttra v\u00e5r v\u00e4rld och m\u00e4nniskors villkor.\nBeskrivning av arbetsplatsen\nPostdoktorstj\u00e4nsten \u00e4r placerad i forskargruppen Cellul\u00e4r biomekanik inom forskningsmilj\u00f6n K\u00e4rlfysiologi vid Institutionen f\u00f6r experimentell medicinsk vetenskap (EMV), Medicinska fakulteten, Lunds universitet. EMV bedriver molekyl\u00e4r, cellul\u00e4r och integrativ forskning p\u00e5 h\u00f6gsta internationella niv\u00e5 och utbildar framtidens framst\u00e5ende forskare.\nForskningsmilj\u00f6n K\u00e4rlfysiologi omfattar tre forskargrupper och cirka tio aktiva forskare. Verksamheten \u00e4r lokaliserad till BMC D12 och har tillg\u00e5ng till 300 m\u00b2 laboratorie- och kontorsytor med modern infrastruktur f\u00f6r fysiologi och cellbiologi. Milj\u00f6n inkluderar tv\u00e5 professorer, tv\u00e5 lektorer samt doktorander, postdoktorer och teknisk personal. Kompetensen omfattar transgena modeller, in vivo-fysiologi och avancerad bioinformatik, med n\u00e4ra koppling till universitets-plattformar f\u00f6r avbildning och omik.\nDen rekryterade forskaren kommer att studera komplementsystemets betydelse vid \u00e5ldersrelaterad k\u00e4rlsjukdom. Arbetet omfattar utveckling och karakterisering av transgena modeller som efterliknar \u00e5ldersrelaterade f\u00f6r\u00e4ndringar i komplementaktivitet. Postdoktorn deltar \u00e4ven i p\u00e5g\u00e5ende samarbetsprojekt, d\u00e4ribland ett aktivt samarbete med forskare vid K\u00f6penhamns universitet inom ett initiativ finansierat av Novo Nordisk Stiftelsen.\nInstitutionen erbjuder en inkluderande forskningsmilj\u00f6 pr\u00e4glad av respekt, \u00f6ppenhet och samarbete. Professionell utveckling uppmuntras genom flexibla arbetsvillkor som fr\u00e4mjar v\u00e4lbefinnande. Med fokus p\u00e5 j\u00e4mst\u00e4lldhet, ett strukturerat ledarskap samt ett v\u00e4lutvecklat arbetsmilj\u00f6arbete erbjuder EMV en h\u00e5llbar och stimulerande milj\u00f6 f\u00f6r forskning och karri\u00e4rutveckling.\nProjektbeskrivning\nV\u00e5r forskning kombinerar experimentella angreppss\u00e4tt med analyser av humant biobanksmaterial och kliniska databaser f\u00f6r att f\u00f6rst\u00e5 hur mekaniska krafter reglerar genuttryck. Vi har nyligen kartlagt transkriptomf\u00f6r\u00e4ndringar i art\u00e4rer hos \u00e5ldrande m\u00e4nniskor och gnagare (https:\/\/doi.org\/10.1016\/j.jbc.2025.108400;\u00a0https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.125.26119) och str\u00e4var nu efter att klarl\u00e4gga de bakomliggande mekanismerna genom att utveckla transgena modeller och unders\u00f6ka deras betydelse f\u00f6r k\u00e4rlfunktion och k\u00e4rlsjukdom.\u00a0\nEtt centralt m\u00e5l \u00e4r att modellera \u00f6kat uttryck av komplementsystemet i \u00e5ldrande art\u00e4rer, d\u00e4r post-doktorn f\u00f6rv\u00e4ntas medverka i samarbetsprojekt med K\u00f6penhamns universitet och G\u00f6teborgs universitet. Arbetet finansieras av flera stora svenska forskningsfinansi\u00e4rer, med specifikt st\u00f6d f\u00f6r postdoktorstj\u00e4nsten fr\u00e5n Novo Nordisk Stiftelsen (https:\/\/novonordiskfonden.dk\/en\/grant-recipient\/?category=72&paginate=1&sort=DESC&search=metabolic+ageing). Tj\u00e4nsten ger goda m\u00f6jligheter att utveckla en sj\u00e4lvst\u00e4ndig och internationellt konkurrenskraftig forskningsprofil i ledande nordiska forskningsmilj\u00f6er.\nProjektet ing\u00e5r i Novo Nordisk Stiftelsens satsning Metabolic Ageing \u2013 Collaborative Project Grants, vilket ger m\u00f6jlighet att delta i gemensamma workshops, symposier, forskningsutbyte och andra n\u00e4tverks- och spridningsaktiviteter tillsammans med lierade forskargrupper som studerar metabolt \u00e5ldrande.\nArbetsuppgifter och ansvarsomr\u00e5den\nVid Lunds universitet ska en anst\u00e4llning som postdoktor ge m\u00f6jlighet till vetenskaplig och pedagogisk meritering. I f\u00f6rsta hand ges utrymme f\u00f6r meritering inom forskning, men \u00e4ven till viss h\u00f6gskolepedagogisk utbildning. Undervisning kan \u00e4ven ing\u00e5 i arbetsuppgifterna.\nFlera komplementfaktorer \u00f6kar i art\u00e4rv\u00e4ggen med stigande \u00e5lder. Eftersom komplementfaktor H (Cfh) begr\u00e4nsar komplementaktivering p\u00e5 v\u00e4vnadsytor utg\u00f6r vaskul\u00e4r knockout av Cfh en syntetisk modell f\u00f6r \u00e5ldrande som f\u00f6rv\u00e4ntas fr\u00e4mja patologiska processer s\u00e5som ateroskleros och aneurysmbildning.\nF\u00f6r att unders\u00f6ka detta kommer du att generera cell-specifika och inducerbara knockoutm\u00f6ss genom att korsa endoteliala (Tie1) och glatta muskelcellspecifika (Itga8) Cre-linjer med m\u00f6ss som b\u00e4r floxade Cfh-alleler (https:\/\/mice.jax.org\/). Genotypning utf\u00f6rs externt, men du ansvarar f\u00f6r koloni- och biopsihantering, inklusive avelsstrategi, burplanering och tamoxifenbehandling f\u00f6r inducerbara knockoutmodeller. Du planerar och genomf\u00f6r \u00e4ven experiment i n\u00e4ra samarbete med kollegor, vilket vid enstaka tillf\u00e4llen kan inneb\u00e4ra arbete utanf\u00f6r ordinarie arbetstid.\nVaskul\u00e4ra fenotyper analyseras med histologiska och fysiologiska metoder, inklusive sjukdomsmodeller baserade p\u00e5 hyperkolesterolemi och hypertoni. \u00c4ven systemisk komplementaktivering och eventuell njurp\u00e5verkan kommer att unders\u00f6kas. Ut\u00f6ver att leda arbetet med Cfh-modellerna samarbetar du n\u00e4ra v\u00e5ra forskningspartners vid K\u00f6penhamns universitet och bidrar till p\u00e5g\u00e5ende studier av mekanoreglerad transkription i k\u00e4rlv\u00e4ggen.\nDu f\u00f6rv\u00e4ntas presentera dina resultat vid internationella konferenser, inom forskningsmilj\u00f6n och i det bredare samarbetsn\u00e4tverket. Finansieringen fr\u00e5n Novo Nordisk Stiftelsen omfattar ett \u00e5rligt resebidrag f\u00f6r deltagande i symposier samt medel f\u00f6r driftkostnader och laboratoriekostnader (bench fee).\nKvalifikationer\nKrav f\u00f6r anst\u00e4llningen \u00e4r:\nDoktorsexamen eller motsvarande utl\u00e4ndsk examen inom fysiologi, farmakologi, molekyl\u00e4rbiologi eller experimentell medicinsk vetenskap. Doktorsexamen ska vara avlagd, alternativt avhandlingen inl\u00e4mnad och godk\u00e4nd f\u00f6r disputation, senast vid tidpunkten d\u00e5 beslut om anst\u00e4llning fattas.\nGod f\u00f6rm\u00e5ga att utveckla och genomf\u00f6ra forskning av god kvalitet.\nPedagogisk f\u00f6rm\u00e5ga.\nGod samarbetsf\u00f6rm\u00e5ga samt f\u00f6rm\u00e5ga att arbeta sj\u00e4lvst\u00e4ndigt.\nMycket god f\u00f6rm\u00e5ga att kommunicera p\u00e5 engelska i tal och skrift, med f\u00f6rm\u00e5ga att tydligt presentera forskningsresultat och kommunicera med s\u00e5v\u00e4l den egna forskningsgruppen som externa samarbetspartners och andra intressenter.\n\nV\u00e4nligen se annonsen i sin helhet via denna l\u00e4nk: https:\/\/lu.varbi.com\/what:job\/jobID:955286\/","price":null,"currency":"SEK","status":"active","noindex":false,"location":{"address":"BMC F13","full_address":null,"city":"Lund","country":"SE","latitude":55.7205201,"longitude":13.1642678},"metadata":{"region":"Sk\u00e5ne l\u00e4n","duration":"6 m\u00e5nader eller l\u00e4ngre","employer":"LUNDS UNIVERSITET","postcode":"22184","positions":1,"profession":"Postdoktor\/Postdoc","salary_type":"Fast m\u00e5nads- vecko- eller timl\u00f6n","employer_url":"https:\/\/www.lu.se\/vacancies","scope_of_work":"100\u2013100 %","working_hours":"Heltid","contact_person":"Karl Sw\u00e4rd","employment_type":"Vanlig anst\u00e4llning","occupation_field":"Pedagogik","employer_workplace":"Lunds universitet, Institutionen f\u00f6r experimentell medicinsk vetenskap","experience_required":true},"user_id":null,"is_sponsored":false,"views_count":4,"ai_views_count":5,"ai_vendor_counts":{"openai":3,"anthropic":2},"visibility":"public","submission_source":null,"submission_ai_name":null,"has_owner_email":true,"can_contact_owner":true,"phone":"072-7431022","owner_email":"karl.sward@med.lu.se","images":[],"published_at":"2026-08-11T13:42:44+00:00","expires_at":"2026-08-25T23:59:59+00:00","created_at":"2026-08-15T03:13:41+00:00","updated_at":"2026-08-19T05:19:17+00:00"}}