{"data":{"id":200475,"slug":"postdoktor-i-rollen-av-exporterade-proteiner-i-malariainfektion","type":"job","title":"Postdoctoral Researcher in \"The Role of Exported Proteins in Malaria Infection\"","description":"Ume\u00e5 University is one of Sweden's largest institutions of higher education with over 41,500 students and approximately 4,600 employees. The university offers a diverse range of high-quality educational programs and world-leading research in several scientific fields. Here, the groundbreaking discovery of the gene scissors CRISPR-Cas9 was made, which was awarded the Nobel Prize in Chemistry. At Ume\u00e5 University, everything is close by. Our cohesive campus makes it easy to meet, collaborate, and exchange knowledge, something that fosters a dynamic and open culture.\nThe Department of Molecular Biology is seeking a postdoctoral researcher for a fixed-term full-time position of two years with a start date of November 1, 2026, or by agreement.\n\nProject Description and Responsibilities\nMalaria is caused by Plasmodium parasites that invade and multiply inside red blood cells. The disease arises from the destruction of red blood cells and the sequestration of infected cells in the microvasculature within the body's organs, a process called organ sequestration. To establish a replicative niche, obtain nutrients, excrete waste products, and adhere to the microvasculature, the parasite exports hundreds of proteins into the infected host cell. Genetic screens have identified which of these exported parasite proteins are important for infection during the blood stage. However, for the majority of exported proteins, it remains unknown which cellular processes they actually participate in.\nThis project will utilize Plasmodium berghei, a malaria model parasite that infects rodents and whose genome can be manipulated efficiently, to systematically investigate the role of exported parasite proteins in malaria infection and disease.\nYou will develop and apply scalable genetic tools and new analytical methods to identify parasite genes encoding exported proteins that are important for the parasite's invasion of host cells, replication, and organ sequestration. The most promising candidate genes will be studied further through in-depth studies in both P. berghei and the human malaria parasite Plasmodium falciparum.\nYou will also perform experimental and bioinformatic work, design experiments, present your results, write manuscripts, assist in supervising students, and actively contribute to a collegial and inclusive laboratory culture.\n\nQualifications\nTo be eligible for employment as a postdoctoral researcher, you must hold a doctorate degree or a foreign degree assessed as equivalent to a Swedish doctorate in biological sciences. This qualification requirement must be met by the time the employment decision is made.\nYou should be highly motivated and able to work productively both as part of a team and independently. Excellent communication skills to interact effectively with colleagues and other staff are required. Good skills in written and spoken English are also required. Great emphasis will be placed on personal suitability.\nThe applicant should have experience with molecular cloning methods, such as design and construction of gene vectors and practical experience with CRISPR\/Cas9. Experience with cultivation and transfection of eukaryotic parasites and experience and training in laboratory animal science (rodents) are required.\n\nMeritorious Qualifications\nSince employment as a postdoctoral researcher constitutes a merit-building position for junior researchers, we primarily target those who hold a doctorate degree no older than three years from the final application deadline. If there are special reasons, someone who obtained their doctorate earlier may be considered. Special reasons include leave due to illness, parental leave, clinical service, positions of trust within trade unions, or other similar circumstances, or service\/assignments relevant to the field of study.\nExperience with advanced confocal microscopy, immunofluorescence, and FACS is highly desirable.\nAs an employee with us, you contribute to promoting an inclusive culture and a positive work environment. This means that you communicate effectively across differences, demonstrate willingness to collaborate, and have the ability to work together. You maintain openness and a welcoming attitude, and you show respect, compassion, and empathy. You engage in and support colleagues from different backgrounds and with different perspectives, and you promote a healthy balance between work and personal life for both yourself and others.\n\nMore About the Position\nThe employment is a full-time fixed-term position of two years in accordance with the conditions of the agreement on fixed-term employment as a postdoctoral researcher.\nYou will be based in Ellen Bushell's laboratory at the Department of Molecular Biology, Ume\u00e5 University. The Bushell lab is part of The Laboratory of Molecular Infection Medicine Sweden (MIMS), which serves as the Swedish node within the Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine.\nMore information about the group's research can be found on our website: Ellen Bushell.\nFor more information about the Department of Molecular Biology and MIMS, please visit our websites: Department of Molecular Biology and MIMS.\n\nApplication\nThe application should be written in Swedish or English. Applications should be submitted through our e-recruitment system Varbi and must be received no later than September 30, 2026.\nA complete application should include:\nA brief description of your research interests and motivation for why you are interested in this position.\nCV\nList of publications\nDiplomas from doctoral studies and other relevant degrees\nContact information for two designated referees\n\nWe welcome your application!\nUme\u00e5 University aims to offer an equal and equitable environment where open dialogue between people with different backgrounds and perspectives forms the foundation for learning, creativity, and development. We therefore welcome people with different backgrounds and experiences to apply for this position.\nTo staffing and recruitment companies and to you as a sales representative: We politely but firmly decline direct contact from staffing and recruitment companies and sellers of additional job advertisements.","language":"sv","is_translated":true,"title_original":"Postdoktor i \u201dRollen av exporterade proteiner i malariainfektion\u201d","description_original":"Ume\u00e5 universitet \u00e4r ett av Sveriges st\u00f6rsta l\u00e4ros\u00e4ten med \u00f6ver 41 500 studenter och cirka 4 600 anst\u00e4llda. Vid universitetet finns en m\u00e5ngfald av utbildningar av h\u00f6g kvalitet och v\u00e4rldsledande forskning inom flera vetenskapsomr\u00e5den, och h\u00e4r gjordes den banbrytande uppt\u00e4ckten av gensaxen CRISPR-Cas9 som tilldelats Nobelpriset i kemi. Vid Ume\u00e5 universitet \u00e4r allt n\u00e4ra. V\u00e5ra sammanh\u00e5llna campus g\u00f6r det l\u00e4tt att m\u00f6tas, samarbeta och utbyta kunskap, n\u00e5got som gynnar en dynamisk och \u00f6ppen kultur.\nInstitutionen f\u00f6r molekyl\u00e4rbiologi s\u00f6ker en postdoktor f\u00f6r en tidsbegr\u00e4nsad anst\u00e4llning p\u00e5 tv\u00e5 \u00e5r motsvarande heltid med tilltr\u00e4de 1 november 2026 eller enligt \u00f6verenskommelse.\n\u00a0\nProjektbeskrivning och arbetsuppgifter\nMalaria orsakas av Plasmodium-parasiter som invaderar och f\u00f6r\u00f6kar sig inuti r\u00f6da blodkroppar. Sjukdomen uppst\u00e5r till f\u00f6ljd av att de r\u00f6da blodkropparna f\u00f6rst\u00f6rs och att infekterade celler f\u00e4ster i mikrovaskulaturen inne i kroppens organ, en process som kallas organsekvestrering. F\u00f6r att kunna etablera en replikativ nisch, ta upp n\u00e4ring och uts\u00f6ndra avfallsprodukter, samt f\u00e4sta i mikrovaskulaturen, s\u00e5 exporterar parasiten hundratals proteiner in i den infekterade v\u00e4rdcellen. Genetiska screens har kartlagt vilka av dessa exporterade parasitproteiner som \u00e4r viktiga f\u00f6r infektion under blodstadiet. F\u00f6r majoriteten av de exporterade proteinerna \u00e4r det dock fortfarande ok\u00e4nt vilka cellul\u00e4ra processer de faktiskt deltar i.\nDetta projekt kommer att utnyttja Plasmodium berghei, en malariamodellparasit som infekterar gnagare och vars genom kan manipuleras effektivt, f\u00f6r att systematiskt unders\u00f6ka rollen hos exporterade parasitproteiner vid malariainfektion och sjukdom.\nDu kommer att utveckla och till\u00e4mpa skalbara genetiska verktyg samt nya analysmetoder f\u00f6r att identifiera de parasitgener som kodar f\u00f6r exporterade proteiner av betydelse f\u00f6r parasitens invasion av v\u00e4rdceller, f\u00f6r\u00f6kning och organsekvestrering. De mest intressanta kandidatgenerna kommer att studeras vidare genom f\u00f6rdjupade studier i s\u00e5v\u00e4l P. berghei som m\u00e4nniskomalariaparasiten Plasmodium falciparum.\u00a0\nDu kommer vidare att utf\u00f6ra experimentellt och bioinformatiskt arbete, designa experiment, presentera dina resultat, skriva manuskript, hj\u00e4lpa till med handledning av studenter samt aktivt medverka till en kollegial och inkluderande labbkultur.\n\u00a0\nBeh\u00f6righet\u00a0\nBeh\u00f6rig att anst\u00e4llas som postdoktor \u00e4r den som avlagt doktorsexamen, eller utl\u00e4ndsk examen som bed\u00f6ms motsvara doktorsexamen, inom biologisk vetenskap. Detta beh\u00f6righetskrav ska vara uppfyllt senast vid tidpunkten d\u00e5 anst\u00e4llningsbeslutet fattas.\u00a0\nDu ska vara mycket motiverad och kunna arbeta produktivt i ett team s\u00e5v\u00e4l som sj\u00e4lvst\u00e4ndigt. Utm\u00e4rkta kommunikationsf\u00f6rm\u00e5gor f\u00f6r att interagera effektivt med kollegor och andra medarbetare kr\u00e4vs. Goda kunskaper i skriftlig och muntlig engelska \u00e4r ocks\u00e5 ett krav. Stor vikt kommer att l\u00e4ggas vid personlig l\u00e4mplighet.\nDen s\u00f6kande ska ha erfarenhet av molekyl\u00e4ra kloningsmetoder, s\u00e5som design och konstruktion av genvektorer och praktisk erfarenhet av CRISPR\/Cas9. Erfarenhet av odling och transfektion av eukaryota parasiter samt erfarenhet och utbildning inom f\u00f6rs\u00f6ksdjursvetenskap (gnagare) kr\u00e4vs.\n\u00a0\nMeriterande\u00a0\nEftersom anst\u00e4llning som postdoktor utg\u00f6r en meriteringsanst\u00e4llning f\u00f6r juniora forskare riktar vi oss fr\u00e4mst till den som har en doktorsexamen som inte \u00e4r \u00e4ldre \u00e4n tre \u00e5r r\u00e4knat fr\u00e5n sista ans\u00f6kningsdag. Om det finns s\u00e4rskilda sk\u00e4l kan den komma i fr\u00e5ga som avlagt doktorsexamen tidigare. Med s\u00e4rskilda sk\u00e4l avses ledighet p\u00e5 grund av sjukdom, f\u00f6r\u00e4ldraledighet, klinisk tj\u00e4nstg\u00f6ring, f\u00f6rtroendeuppdrag inom fackliga organisationer eller andra liknande omst\u00e4ndigheter, eller f\u00f6r \u00e4mnesomr\u00e5det relevant tj\u00e4nstg\u00f6ring\/uppdrag.\u00a0\nErfarenhet av avancerade konfokal mikroskopi, immunofluorescence och FACS \u00e4r mycket \u00f6nskv\u00e4rt.\u00a0\nSom medarbetare hos oss bidrar du till att fr\u00e4mja en inkluderande kultur och en positiv arbetsmilj\u00f6. Detta inneb\u00e4r att du kommunicerar effektivt \u00f6ver olikheter, visar samarbetsvilja och f\u00f6rm\u00e5ga att samarbeta. Du uppr\u00e4tth\u00e5ller \u00f6ppenhet och en v\u00e4lkomnande attityd samt visar respekt, medk\u00e4nsla och empati. Du engagerar dig i och st\u00f6ttar kollegor fr\u00e5n olika bakgrunder och med olika perspektiv, och du fr\u00e4mjar en h\u00e4lsosam balans mellan arbete och privatliv f\u00f6r b\u00e5de dig sj\u00e4lv och andra.\n\u00a0\nMer om anst\u00e4llningen\nAnst\u00e4llningen \u00e4r en tidsbegr\u00e4nsad anst\u00e4llning p\u00e5 heltid i tv\u00e5 \u00e5r enligt villkoret i avtalet om tidsbegr\u00e4nsad anst\u00e4llning som postdoktor.\nDu kommer att vara baserad i Ellen Bushells laboratorium vid Institutionen f\u00f6r molekyl\u00e4rbiologi, Ume\u00e5 universitet. Bushell-labbet \u00e4r en del av The Laboratory of Molecular Infection Medicine Sweden (MIMS), som utg\u00f6r den svenska noden inom Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine.\u00a0\nMer information om gruppens forskning finns att l\u00e4sa p\u00e5 v\u00e5r hemsida: Ellen Bushell.\nF\u00f6r mer information om Institutionen f\u00f6r molekyl\u00e4rbiologi och MIMS v\u00e4nligen bes\u00f6k v\u00e5ra hemsidor: Institutionen f\u00f6r molekyl\u00e4rbiologi och MIMS.\n\u00a0\nAns\u00f6kan\nAns\u00f6kan ska vara skriven p\u00e5 svenska eller engelska. Ans\u00f6kan ska g\u00f6ras via v\u00e5rt e-rekryteringssystem Varbi och vara inkommen senast den 30 september 2026.\u00a0\u00a0\nEn fullst\u00e4ndig ans\u00f6kan ska inneh\u00e5lla:\nEn kort beskrivning av forskningsintressen och motivering till varf\u00f6r du \u00e4r intresserad av anst\u00e4llningen.\nCV\nPublikationslista\nExamensbevis fr\u00e5n forskarutbildning samt andra relevanta examina\nKontaktuppgifter till tv\u00e5 vidtalade referenspersoner\n\nV\u00e4lkommen med din ans\u00f6kan!\nUme\u00e5 universitet vill erbjuda en j\u00e4mst\u00e4lld och j\u00e4mlik milj\u00f6 d\u00e4r \u00f6ppna samtal mellan m\u00e4nniskor med olika bakgrund och perspektiv l\u00e4gger grunden f\u00f6r l\u00e4rande, skaparkraft och utveckling. Vi v\u00e4lkomnar d\u00e4rf\u00f6r personer med olika bakgrunder och erfarenheter att s\u00f6ka den aktuella anst\u00e4llningen.\nTill bemannings- och rekryteringsf\u00f6retag och till dig som \u00e4r f\u00f6rs\u00e4ljare: Vi undanber oss v\u00e4nligen men best\u00e4mt direktkontakt med bemannings- och rekryteringsf\u00f6retag samt f\u00f6rs\u00e4ljare av ytterligare jobbannonser.","price":null,"currency":"SEK","status":"active","noindex":true,"location":{"address":"Ume\u00e5 universitet","full_address":null,"city":"Ume\u00e5","country":"SE","latitude":63.7970413,"longitude":20.2816791},"metadata":{"region":"V\u00e4sterbottens l\u00e4n","duration":"6 m\u00e5nader eller l\u00e4ngre","employer":"Ume\u00e5 Universitet","postcode":"90187","positions":1,"profession":"Molekyl\u00e4rbiolog","salary_type":"Fast m\u00e5nads- vecko- eller timl\u00f6n","employer_url":"https:\/\/www.umu.se\/jobba-hos-oss\/","scope_of_work":"100\u2013100 %","working_hours":"Heltid","contact_person":"Ellen Bushell","employment_type":"full_time","occupation_field":"Naturvetenskap","employer_workplace":"Ume\u00e5 universitet, Medicinska fakulteten","employment_type_label":"Vanlig anst\u00e4llning"},"user_id":null,"is_sponsored":false,"views_count":1,"ai_views_count":11,"bot_views_count":3,"ai_vendor_counts":{"meta":4,"other":6,"anthropic":1},"visibility":"public","submission_source":null,"submission_ai_name":null,"has_owner_email":true,"can_contact_owner":true,"phone":null,"owner_email":"ellen.bushell@umu.se","images":[],"published_at":"2026-09-08T10:35:18+00:00","expires_at":"2026-09-30T23:59:59+00:00","created_at":"2026-09-09T03:24:02+00:00","updated_at":"2026-09-20T02:58:39+00:00"}}